Experimental model of glucocorticoid-induced insulin resistance
نویسندگان
چکیده
منابع مشابه
Angiopoietin-like 4 in glucocorticoid induced insulin resistance
Glucocorticoids play a key role in metabolic adaptation during stress. The major metabolic function of glucocorticoids is to preserve plasma the glucose levels that serve as the major energy source for the brain [1]. Therefore, glucocorticoids antagonize the ability of insulin to suppress hepatic gluconeogenesis and promote glucose utilization in white adipose tissue (WAT) and skeletal muscle [...
متن کاملProbiotics improve insulin resistance status in an experimental model of Alzheimer’s disease
Background: Nowadays, Alzheimer’s disease (AD) is considered as Type 3 diabetes in which insulin resistance is the common cause of both diseases. Disruption of insulin signaling cascade and insulin resistance can induce AD; and central insulin resistance causes systemic alterations in serum insulin, FBS levels, and lipid profile. Studies have shown that probiotics (Lact...
متن کاملEffect of Vanadyl Sulfate on Fructose-Induced Insulin Resistance Rat
Insulin resistance syndrome, also referred to as the metabolic syndrome or syndrome X, refers to a constellation of common metabolic and cardiovascular disorders (e.g. obesity, type 2 diabetes mellitus, hypertension, and dyslipidemia), which are all cardiovascular risk factors. Insulin resistance can be induced by fructose-rich diet in rats. We investigated the effect of vanadyl sulfate (0.2 mg...
متن کاملRheumatoid arthritis - a neuroendocrine immune disorder: glucocorticoid resistance, relative glucocorticoid deficiency, low-dose glucocorticoid therapy, and insulin resistance
sighted work of Philip S Hench, who together with Edward C Kendall and Tadeus Reichstein introduced glucocorticoids (GCs) into clinical medicine. Since the 1990s, more than 40 years after adding GC to the therapeutic armamentarium, important work has been carried out to understand GC action. Th ere were three major pathways of discoveries between 1990 and today. Firstly, the groups of George Ch...
متن کاملNew mechanisms of glucocorticoid-induced insulin resistance: make no bones about it.
Glucocorticoids are a powerful tool used to treat a range of human illnesses, including autoimmune diseases and cancer, and to prevent rejection following organ transplantation. While lifesaving for many, they come with a steep price, often leading to obesity, insulin resistance, diabetes, and osteoporosis. In this issue of the JCI, Brennan-Speranza and colleagues provide evidence that the oste...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Acta Cirurgica Brasileira
سال: 2016
ISSN: 0102-8650
DOI: 10.1590/s0102-865020160100000001